NCT03920332

Pregnancy and Fibrinogen Disorders

Obstetric Outcomes of Women Suffering From Hereditary Fibrinogen Disorders

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 149 (actual)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this observational study is to evaluate the prevalence of uncomplicated pregnancies in women suffering from congenital fibrinogen disorders (i.e, hypofibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia) as well as to describe pregnancies outcomes in such diseases.

Detailed description

Women with quantitative or qualitative fibrinogen disorders are often more prone to obstetrical complications, from bleeding to recurrent miscarriages or thrombosis. Data on fibrinogen levels variations throughout the pregnancy and on the delivery management are lacking. In this observational study will be include adult women with pas obstetrical history. A general questionnaire on demographics and clinical data will be filled out by the patient's physician. A detailed questionnaire on obstetrical data will also be completed contacting the patient in case of lacking data.

Conditions

• Hypofibrinogenemia, Congenital
• Afibrinogenemia, Congenital
• Dysfibrinogenemia, Congenital

Timeline

• Start date: 2019-09-01
• Primary completion: 2022-05-01
• Completion: 2022-05-01
• First posted: 2019-04-18
• Last updated: 2022-11-02

Locations

3 sites across 3 countries: France, Slovakia, Switzerland