NCT03916978

Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women

Investigating Reactivation of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in Menopausal Women

• Status: Recruiting
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Genesis Athens Clinic · Academic / Other
• Sex: Female
• Age: 45 Years – 55 Years
• Healthy volunteers: Accepted

Summary

Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve hormonal profile of women in menopause.

Detailed description

This triple-blind Randomized Controlled Trial (RCT) aims to investigate the effectiveness of autologous PRP intra ovarian infusion on reactivating ovarian functionality and on promoting folliculogenesis in regard to menopausal women. PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. It is collected from peripheral veins and contains several growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factor (TGF) and other cytokines all of which stimulate tissue proliferation and growth. PRP has been employed in several medical conditions in Orthopedics, Dermatology, and Ophthalmology for wound healing. It's efficacy in ovarian rejuvenation and reactivation and endometrial regeneration has not been fully elucidated. This study aims to investigate the effect of autologous PRP intra ovarian infusion on restoring ovarian tissue functionality in menopausal women.

Conditions

• Infertility, Female
• Anovulatory Infertility
• Menopause
• Amenorrhea

Interventions

Type	Name	Description
BIOLOGICAL	Autologous PRP intra ovarian infusion	Autologous PRP intra ovarian infusion
BIOLOGICAL	Autologous PFP intra ovarian infusion	Autologous PFP intra ovarian infusion

Timeline

• Start date: 2019-05-21
• Primary completion: 2026-01-30
• Completion: 2026-07-30
• First posted: 2019-04-16
• Last updated: 2024-12-27

Locations

1 site across 1 country: Greece