NCT03913650

The Influence of Peripheral Nerve Blocks in Patients Undergoing Limb Orthopedic Surgery

Preoperative Peripheral Nerve Blocks Attenuate Intraoperative Surgical Stress and Postoperative Pain in Patients Undergoing Orthopedic Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To investigate pre-op peripheral nerve block in reducing peri-op IL-6 level and post-op pain

Detailed description

In orthopedic surgery, peripheral nerve block can be used as an anesthesia adjuvant prior to surgery. In this study, we hypothesized that peripheral nerve blocks may alleviate inflammatory response and reduce the analgesics requirement. Sixty patients undergoing limb orthopedic surgery will be enrolled. Peripheral nerve block was injected with 0.25% bupivacaine under ultrasound guidance. 30 patients (Study group) underwent surgery with nerve blocks and another 30 patients (Control group) underwent surgery with morphine. The anesthetic protocol was standardized for both groups by experienced anesthesiologists. Surgical stress was assessed by blood pressure fluctuation and proinflammatory cytokine. Pain intensity was measured by numeric rating scale (NRS) score for 24 hours

Conditions

• Pain, Postoperative
• Change; Circulatory
• Surgical Injury

Interventions

Type	Name	Description
PROCEDURE	0.25% bupivacaine	nerve block procedure will be decided by patients' will for post-op pain

Timeline

• Start date: 2017-05-15
• Primary completion: 2018-11-30
• Completion: 2018-12-31
• First posted: 2019-04-12
• Last updated: 2020-02-18

Locations

2 sites across 1 country: Taiwan