NCT03909191

Serum HBV RNA Value on Chronic Hepatitis B Virus Infection Manage

Serum HBV RNA Level Monitoring During Chronic Hepatitis B Virus Infection Especialy in Patients Undergoing Long-term Nucleos(t)Ide Analoguage Treatment

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 454 (actual)
• Sponsor: Changhai Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

As an alternative biomarker of intrahepatic covalently closed circular DNA(cccDNA) transcriptional activity, hepatitis B virus(HBV)RNA may evolve during long-lasting virus-host interactionsduring chronic hepatitis B viral infection.The distribution pattern of serum HBV RNA levels in the natural course of chronic HBV infection remains unclear. Furthermore,serum HBV RNA was associated with response to NAs. So it may be another clinical surrogate marker for intrahepatic cccDNA level after long-term NAs treatment and be used to monitor NAs therapy. The aim of this study was to evaluate thelevels of HBV RNA during the natural courseof CHB and the role in distinguishingthe natural phases of HBV infection and to investigate whether serum HBV RNA level at the end of long-term NAs treatment had a similar or better predict effect on off-therapy relapse than serum HBsAg titer.

Conditions

• Chronic HBV Infection
• Drug Withdrawal

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	serum HBV RNA	serum HBV RNA level was determined by using HBV-SAT kit at different time point

Timeline

• Start date: 2016-02-01
• Primary completion: 2020-05-01
• Completion: 2020-05-01
• First posted: 2019-04-09
• Last updated: 2021-02-02