NCT03907722

The 3q25 rs2305619 Polymorphism Associates With Microvascular Obstruction in STEMI

The 3q25 rs2305619 Polymorphism is Associated With Coronary Microvascular Obstruction Following Primary Angioplasty for Acute ST-segment Elevation Myocardial Infarction

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 217 (actual)
• Sponsor: Indonesian Cardiovascular Research Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The investigators enrolled 217 patients with acute STEMI undergoing primary PCI. The rs2305619 polymorphism was evaluated by real time PCR and plasma PTX3 concentration was assessed by human PTX3 ELISA kit.

Detailed description

The investigators enrolled 217 patients with acute STEMI undergoing primary PCI in a tertiary care academic cardiovascular center. The rs2305619 polymorphism was evaluated by real time PCR and plasma PTX3 concentration was assessed by human PTX3 ELISA kit. The primary outcome of the study was the incidence of coronary microvascular obstruction defined as thrombolysis in myocardial infarction (TIMI) grade \<3 flow after primary PCI or TIMI grade 3 flow with myocardial blush grade 0 or 1. Patients were grouped based on the genotypic variants (AA, AG and GG). The primary outcome was compared among the three variants, as well as the PTX3 concentration and 30-day mortality.

Conditions

• STEMI
• Microvascular Coronary Artery Disease

Interventions

Type	Name	Description
OTHER	Long pentraxin 3	Primary PCI

Timeline

• Start date: 2018-01-01
• Primary completion: 2018-08-02
• Completion: 2018-09-03
• First posted: 2019-04-09
• Last updated: 2019-04-11

Locations

1 site across 1 country: Indonesia