NCT03902912

Effect of Prednisolone Treatment on Uterine Natural Killer Cells

Effect of Prednisolone Treatment on Uterine Natural Killer Cells and Endometrial Angiogenesis in Recurrent Miscarriage Around the Time of Embryo Implantation

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 84 (estimated)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate the role of uNK cells and the association with prednisolone.

Detailed description

Glucocorticoids prednisolone is considered as a potential therapy in women with recurrent miscarriage. However, the evidence for treatment with prednisolone is still inconclusive and the relevant mechanism merits further investigations. The participants will be invited to take prednisolone oral 10 mg/day and attend our outpaitent clinic to be performed endometrial biopsy.

Conditions

• Recurrent Miscarriage

Interventions

Type	Name	Description
DRUG	Prednisolone	prednisolone oral 10 mg/day from day one of the subsequent menstrual cycle to day LH 7 of that cycle. Then, the participants will be given a tailing off dose of 5 mg/day for 3 days followed by 2 mg/day for 3 days and then 1 mg/day for 3 days.

Timeline

• Start date: 2019-07-30
• Primary completion: 2027-04-30
• Completion: 2028-04-30
• First posted: 2019-04-04
• Last updated: 2025-03-21

Locations

1 site across 1 country: Hong Kong