NCT03901716

Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation

Comparison of Sufentanil, Fentanyl and Remifentanil in Combination With Midazolam During Bronchoscopy Under Conscious Sedation: A Randomized Double-blind Prospective Study

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Guangzhou Institute of Respiratory Disease · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The best opioid for bronchoscopy is still unclear.This randomized double-blind prospective study was conducted on a total of 60 patients who were randomly allocated into 3 groups: Group S received sufentanil 0.1 mcg/kg, Group F received fentanyl 1 mcg/kg and Group R received remifentanil target-controlled infusion with effect-site target concentration of 1ng/ml. Patients in all groups received midazolam to achieve moderate levels of sedation as assessed by the Narcotrend (NT; between B1 and C2). Adverse events, patient tolerance and physician satisfaction were analized.

Conditions

• Sufentanil
• Remifentanil
• Fentanyl
• Bronchoscopy
• Narcotrend
• Conscious Sedation

Interventions

Type	Name	Description
DRUG	Sufentanil	Patients in Group S received sufentanil 0.1 mcg/kg.
DRUG	Fentanyl	Patients in Group F received fentanyl 1 mcg/kg.
DRUG	Remifentanil	Patients in Group R received remifentanil target-controlled infusion with effect-site target concentration of 1ng/ml.
DRUG	Midazolam	Patients in all groups received midazolam to achieve moderate levels of sedation as assessed by the Narcotrend (NT; between B1 and C2).

Timeline

• Start date: 2019-01-15
• Primary completion: 2019-03-15
• Completion: 2019-03-26
• First posted: 2019-04-03
• Last updated: 2019-04-03

Locations

1 site across 1 country: China