NCT03901014

Investigating the Production of Lipoproteins and Acetyl-CoA During a Ketogenic Diet

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: Touro University, California · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to understand how the reduction in dietary carbohydrates in a very-low carbohydrate ketogenic diet impacts the synthesis of cholesterol, fatty acid, and ketones, and the turnover rate of VLDL and chylomicron particles.

Detailed description

Participants will consume a standard American diet for one week followed by a very-low carbohydrate ketogenic diet (VLCKD, \<50 grams carbohydrate/day) for two weeks. Participants will undergo an oral stable isotope tracer study during each diet to measure de novo synthesis of fatty acid, cholesterol, ketone bodies, and for measurement of apolipoprotein B and triglyceride kinetics.

Conditions

• Cholesterol Metabolism
• Ketone Metabolism

Interventions

Type	Name	Description
OTHER	Standard American diet	Standard American diet with 50% energy from carbohydrate, 30% from fat, and 20% from protein.
OTHER	Very low carbohydrate diet	Ketogenic diet with \<50g carbohydrate, 60-75% energy from fat, and 20% from protein

Timeline

• Start date: 2019-03-31
• Primary completion: 2019-04-18
• Completion: 2019-04-18
• First posted: 2019-04-03
• Last updated: 2022-11-09

Locations

1 site across 1 country: United States