NCT03893721

Effect of Chronic Arsenic Exposure on Malnutrition of Under Five Children

Effect of Chronic Arsenic Exposure on Malnutrition Among Under-five Children Attending Assiut University Children Hospital

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 2 Years – 5 Years
• Healthy volunteers: Accepted

Summary

Early life malnutrition is associated with later life health problems, Particularly Stunting, which is a height-for-age Z score less than -2 standard deviation of World Health Organization median.Underweight is weight-for-age Z score less than -2 standard deviation of World Health Organization median. Wasting is weight -for- height Z score less than -2 standard deviation of World Health Organization median.

Detailed description

prevalence of under-five stunting, wasting and underweight are 21% and , 8% and 6% respectively in Egyptian Demographic Health Survey 2014. The main risk factors for growth restriction in children are maternal under nutrition during pregnancy, lack of exclusive breastfeeding, inappropriate complementary feeding and micronutrient intake and high prevalence of enteric infections. However, other environmental exposures may also play a role in growth restriction . High concentrations of Arsenic, lead and cadmium in placenta are associated with poor fetal out come and low birth weight. Arsenic crosses the placenta causing suppression of insulin-Like Growth Factor 1. When breastfeeding is exclusive, infants are unlikely to be exposed to Arsenic by other routes of exposure such as external foods, drinking water and foods made at home using Arsenic contaminated water. Rational of the study. Improvement of under-five nutritional status is a global target. Although the exposure to arsenic has increased globally, it's impact on nutritional status has seldom been investigated.

Conditions

• Malnutrition, Child
• Arsenic Poisoning Chronic

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	arsenic exposure	analysis of hair samples for Arsenic using Agilent graphite tube atomizer 120

Timeline

• Start date: 2019-06-01
• Primary completion: 2019-12-01
• Completion: 2020-06-01
• First posted: 2019-03-28
• Last updated: 2019-03-28

Locations

1 site across 1 country: Egypt