NCT03893032

Enhancing Operational Performance in Healthy Rested Soldiers With Pharmacological Stimulants

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: United States Army Aeromedical Research Laboratory · Federal
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Considerable research has documented the optimization utility of stimulants in sleep deprived Soldiers and aviators, however, the research for enhancement purposes has demonstrated mixed results. One significant factor that may influence enhancement properties is general intelligence such that low performers exhibit stronger enhancement effects than high performers. The objective of this study is to determine whether stimulants (specifically, modafinil and Adderall) can enhance Soldier cognitive abilities and performance on military tasks. To do so, a within-subjects design will be employed using healthy, rested Soldiers and measuring performance on a set of basic cognitive assessments and operationally relevant tasks.

Conditions

• Cognition

Interventions

Type	Name	Description
DRUG	Modafinil 200mg	single 200 mg dose
DRUG	mixed amphetamine salts	single 10 mg dose
DRUG	Placebo	single oral-administration placebo tablet

Timeline

• Start date: 2019-07-17
• Primary completion: 2019-10-01
• Completion: 2019-10-01
• First posted: 2019-03-27
• Last updated: 2019-07-31

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study