NCT03890510

The Effect of High vs. Low Fluid Volume on Ocular Parameters in Prone Spine Surgery

Effect of Different Fluid Volume on Ocular Parameters in Patients Undergoing Spine Surgery in Prone Position

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 97 (actual)
• Sponsor: Huashan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this trial is to compare the effect of different fluid volume infusion on ocular parameters in patients undergoing spine surgery in prone position.

Detailed description

In the prone position, the intraocular pressure and optic nerve sheath diameter increase progressively with time as compared with those in the supine position. Excessive fluid infusion may further increase intraocular pressure and optic nerve sheath diameter. Pulse pressure variation (PPV) is a dynamic index which can effectively assess fluid responsiveness during general anesthesia.Therefore,the investigators have designed a study to compare the effect of different fluid volume infusion guided by low and high PPV indices on intraocular pressure and optic nerve sheath of patients undergoing prone spine surgery with general anesthesia. One group of the patients will receive relatively loose fluid infusion (target value of PPV: 6%-9%),while the other group of the patients will receive limited fluid infusion (target value of PPV: 13%-16%).

Conditions

• Prone Position
• Blood Volume
• Intraocular Pressure

Interventions

Type	Name	Description
OTHER	Ringer's Lactate solution	Patients in both groups will receive Ringer's lactate solution continuously during operation with different infusion volume.
PROCEDURE	Spine surgery under general Anesthesia in the prone position	The surgery, general anesthesia, and the placement of the prone position will be performed according to the standard procedures.

Timeline

• Start date: 2019-05-01
• Primary completion: 2020-08-31
• Completion: 2020-09-07
• First posted: 2019-03-26
• Last updated: 2020-12-17

Locations

1 site across 1 country: China