Trials / Completed
CompletedNCT03884543
Driving Pressure During General Anesthesia for Open Abdominal Surgery
Driving Pressure During General Anesthesia for Open Abdominal Surgery (DESIGNATION) - a Randomized Clinical Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 1,468 (actual)
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Academic / Other
- Sex
- All
- Age
- 18 Years – 100 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this international multicenter, patient and outcome-assessor blinded randomized controlled trial is to determine whether the application of an individualized high PEEP strategy, aiming at avoiding an increase in the driving pressure during intraoperative ventilation, protects against the development of postoperative pulmonary complications.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Individualized high PEEP strategy | Patients are randomized and intra-operatively ventilated with an individualized high PEEP strategy (Highest PEEP with the lowest driving pressure with recruitment maneuvers) |
Timeline
- Start date
- 2019-04-23
- Primary completion
- 2025-03-11
- Completion
- 2025-06-01
- First posted
- 2019-03-21
- Last updated
- 2025-11-19
Locations
22 sites across 3 countries: Germany, Italy, Netherlands
Source: ClinicalTrials.gov record NCT03884543. Inclusion in this directory is not an endorsement.