NCT03880851

MR-based Hypofractionated Adaptive IGRT of Prostate Cancer (M-base HyPro 2.0)

Single-arm Phase (II) Study on MR-based Hypofractionated Adaptive Image-guided Radiation Therapy for Prostate Cancer

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 78 (estimated)
• Sponsor: University Hospital Tuebingen · Academic / Other
• Sex: Male
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Single-centre single-armed, non-randomized interventional phase II-study of hypofractionated image-guided radiotherapy "IGRT" with weekly magnetic resonance imagings "MRI" for personalized adaptation of the treatment plan depending on individual MR-anatomy of prostate/organ at risks "OAR" during course of IGRT.

Detailed description

IGRT-schedule: 20 fractions to a total dose of 60 Gy Personalized adaption of treatment plan dependning on volume-/ and constraint-thresholds and evaluation of biomarkers (multiparametric MRI, blood, tissue, stool, urine). Treatment at MR-Linac allowed

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
RADIATION	Plan adaptation of Radiation Treatment in case of anatomical changes	Image guided radiotherapy is given to 60Gy in 20 fractions. Intervention: Radiation treatment plan adaption in case of volume changes of target volume or not meeting OAR constraints due to volume changes.

Timeline

• Start date: 2019-01-23
• Primary completion: 2024-01-31
• Completion: 2024-01-31
• First posted: 2019-03-19
• Last updated: 2019-03-20

Locations

1 site across 1 country: Germany