NCT03880162

Metabolic Effects of a Low Carbohydrate Versus a Standard Diet in Morbidly Obese With Prediabetes

Metabolic Effects of a Low Carbohydrate Versus Energy-matched Standard Diet in Morbidly Obese Individuals With Prediabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Insel Gruppe AG, University Hospital Bern · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To investigate the metabolic effects of a low carbohydrate versus energy-matched standard diet in morbidly obese individuals with prediabetes awaiting bariatric surgery.

Detailed description

The metabolic benefits of calorie restriction in obese people with or without impaired glycaemia are well-established. The impact of diet composition, however, remains poorly understood. Hepatic lipid content strongly correlates with hepatic insulin resistance, which is a key feature of the pre-diabetic state. The investigators hypothesize that a low carbohydrate diet compared to an energy-matched standard diet in morbidly obese patients with prediabetes scheduled for bariatric surgery results in greater reduction in liver fat.

Conditions

• PreDiabetes
• Obesity, Morbid
• Bariatric Surgery Candidate

Interventions

Type	Name	Description
OTHER	Low carbohydrate diet	A energy deficient (30% deficit) low carbohydrate diet (10% of carbohydrates)
OTHER	Energy-matched standard diet	Energy-matched (30% deficit) standard diet (50% of carbohydrates)

Timeline

• Start date: 2019-05-13
• Primary completion: 2024-05-03
• Completion: 2024-05-03
• First posted: 2019-03-19
• Last updated: 2024-12-09

Locations

1 site across 1 country: Switzerland