NCT03879252

Tolerance of Teeth Brushing During Prolonged Aplasia

Tolerance of Teeth Brushing During Prolonged Aplasia In Protected Unit

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 76 (actual)
• Sponsor: University Hospital, Angers · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

It is currently not allowed for patients with prolonged aplasia, following intensive chemotherapy, to brush teeth due to the risk of damaging the oral mucosa with risk of haemorrhage and infectious entrance door. Mouthwash is currently prescribed to prevent these complications. Many patients, however, ask to brush their teeth for greater comfort and a feeling of well-being. Some haematology services allow tooth brushing while others prohibit tooth brushing without study. Investigators wanted to conduct a study to assess the feasibility, the safety of tooth brushing for aplastic patient comfort, hemopathy and/or chemotherapies causing mucous membrane alteration that increases infectious risk and the risk of gingivorragia.

Conditions

• Aplasia

Interventions

Type	Name	Description
DEVICE	Toothbrush	Brushing teeth three times a day (extra-soft toothbrush) with a 1.4% baking mouthwash solution.
DRUG	Mouthwashes	Mouthwashes three times a day with a 1.4% baking mouthwash solution.

Timeline

• Start date: 2019-07-22
• Primary completion: 2023-02-01
• Completion: 2023-02-01
• First posted: 2019-03-18
• Last updated: 2025-12-30

Locations

1 site across 1 country: France