NCT03877185

A New Revolutionary 3-Injection- Protocol in Infertile Women

A New Revolutionary 3-Injection- Protocol in Infertile Women With a Single Long Acting GnRH Antagonist in the Luteal Phase, a Bolus Gonadotropin Injection in the Early Follicular Phase and a Single Triggering Dose.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Assisting Nature · Academic / Other
• Sex: Female
• Age: 22 Years – 39 Years
• Healthy volunteers: Accepted

Summary

This is a prospective randomised study of the evaluation of the clinical IVF results after following a new revolutionary 3-Injection- Protocol for controlled ovarian stimulation in infertile women.

Detailed description

A randomized prospective study focusing on infertile women undergoing ovarian stimulation for IVF, using Elonva (corifollitropin alfa) as part of two different stimulation protocols. Women assigned to Protocol A receive a bolus late luteal dose of Degarelix, a new long acting GnRH antagonist, a sole Elonva injection in the evening of day 3 of the cycle, followed by the administration of a single dose of triggering agent (GnRH agonist or hCG a, according to the individual response). Women assigned to Protocol B are administered a single dose of Elonva (corifollitropin alfa) on day 2 of the cycle, followed by daily GnRH antagonist doses, fixed on day 7 of the cycle. Ovulation triggering is the same as in group A, with either GnRH agonist or hCG a, accordingly. Live Birth Rates are estimated for both groups of patients. The number of the formed blastocysts in each group is measured, as well.

Conditions

• Infertility, Female

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Live birth rate	Live Birth Rate and Blastulation Rate according to the protocol of COS

Timeline

• Start date: 2018-07-01
• Primary completion: 2021-12-01
• Completion: 2021-12-01
• First posted: 2019-03-15
• Last updated: 2020-10-08

Locations

1 site across 1 country: Greece