NCT03875417

Multidisciplinary Management of HCC in Elderly Patients

Multidisciplinary HCC Treatment in Elderly : QoL and Survival Analysis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 126 (actual)
• Sponsor: Azienda Policlinico Umberto I · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Aim of this study is to evaluate whether treating HCC recurrences in resected elderly patients is advantageous or not.

Detailed description

Introduction- Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. It usually develops in cirrhotic liver with high recurrence rates. More than 2/3 of patients are elderly, often excluded from surgery and follow-up protocols. Aim of this study is to evaluate whether treating HCC recurrences in resected elderly patients is advantageous or not. Materials and methods- 126 patients, aged between 65 and 90 years, submitted to liver resection for HCC were enrolled. They were divided into three classes. Class 1 included patients submitted to major resections, Class 2 to minor resections and Class 3 to minor resections associated with thermoablation. All of them were clinically and radiologically followed up. Patients who developed recurrences (Group A) were referred to further treatments (surgery, interventional radiology or pharmacological therapy). Mortality, disease-free survival (DFS), overall survival (OS) and quality of life (QoL) were evaluated and compared with non-recurrent patients (Group B). Used interventional radiology means were Radiofrequency ablation (RF), microwaves ablation (MWA) or transcatheter arterial chemoembolization (TACE).

Conditions

• HCC
• Quality of Life

Interventions

Type	Name	Description
PROCEDURE	liver resection	resection of one or more HCC nodules within the liver
PROCEDURE	Thermic ablation	ablation of HCC nodule through a percutaneous needle, by using radiofrequency or microwaves
PROCEDURE	Transcatheter arterial chemoembolization	embolization of HCC nodule via drug-eluted microbeads.

Timeline

• Start date: 2018-01-01
• Primary completion: 2018-05-30
• Completion: 2018-10-31
• First posted: 2019-03-14
• Last updated: 2019-03-14

Locations

1 site across 1 country: Italy