NCT03874286

The TOGETHER Project - Liver

The Together Project-Transplant Organ Genomics to Help Prevent Rejection in Liver Transplant Recipients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 54 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To validate the use of a RNAseq-based peripheral blood assay in liver transplant recipients when correlated to liver biopsy results.

Detailed description

The study is a prospective, observational study utilizing peripheral blood assays that will be collected at time points that are considered standard of care at most institutions. 100 participants will be enrolled in study. Participants will have peripheral blood collected at 4 months and 12 months after liver transplant, as well as any for cause time points. Participants will also have liver biopsies collected at these time points. The results from the liver biopsies will be used in correlation with the results from the peripheral blood assays.

Conditions

• Liver Transplant Rejection

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Liver Transplant	Patients will obtain a research blood draw and a liver biopsy at 4 months and 12 months post transplant. Liver biopsies are routinely performed in the liver transplant population. We will be obtaining a liver biopsy at this particular time point to compare the biopsy results with the peripheral blood results.

Timeline

• Start date: 2017-03-15
• Primary completion: 2020-04-30
• Completion: 2020-04-30
• First posted: 2019-03-14
• Last updated: 2022-05-20

Locations

3 sites across 1 country: United States