Trials / Completed
CompletedNCT03873948
Evaluation of Arginine in Periodontal and Cardiovascular Disease
Analysis of Serum and Salivary ADMA-Arginine Levels in Patients With Periodontal and Cardiovascular Diseases
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 141 (actual)
- Sponsor
- University of Messina · Academic / Other
- Sex
- All
- Age
- 19 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
Asymmetric dimethylarginine (ADMA) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and coronary heart disease (CHD). The investigators compared the impact of gingival health, periodontitis (CP), CHD or of both diseases (CP+CHD) on saliva and serum ADMA levels.
Detailed description
The aim of this study was to evaluate a possible association between both saliva and serum ADMA levels in patients with CP and with CHD and if the serum ADMA levels are mediated by serum CRP.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Evaluation of arginine serum level | correlation of serum arginine level with periodontal and cardiovascular disease |
Timeline
- Start date
- 2014-01-06
- Primary completion
- 2018-08-08
- Completion
- 2019-03-01
- First posted
- 2019-03-14
- Last updated
- 2019-10-04
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT03873948. Inclusion in this directory is not an endorsement.