NCT03871647

Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG

Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After Coronory Artery Bypass Grafting (CABG) Surgery in Egyptian Patients Receiving Beta Blockers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 256 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients. It is associated with prolonged hospitalization, increased hospital costs, increased complications and mortality rate. Despite the use of Beta Blockers, approximately 20% of patients develop atrial fibrillation following CABG surgery, suggesting a role for polymorphism in the genes The aim of the present study is to determine the minor allele frequency of some of the genes that affect the beta blockers' response and to determine the association between polymorphism in these genes and the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting in Egyptian patients receiving perioperative beta blockers.

Conditions

• Coronary Bypass Graft Surgery
• Atrial Fibrillation

Interventions

Type	Name	Description
DRUG	Beta blocker	perioperative beta blockers

Timeline

• Start date: 2019-03-11
• Primary completion: 2020-12-07
• Completion: 2021-03-07
• First posted: 2019-03-12
• Last updated: 2021-11-09

Locations

1 site across 1 country: Egypt