NCT03870581

AI-based Social Software to Manage wARfarin Therapy

Artificial Intelligence-based Social Software Management Model to Improve Warfarin Anticoagulation Therapy: a Prospective, Single-blind, Randomized Control Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 500 (estimated)
• Sponsor: Wuhan Asia Heart Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The investigators have demonstrated that social software could improve warfarin therapy quality by Human management. however,the efficiency of management will decline if patients' number expands huge. So it is needed that a human-like and automatic management tool could replace the human work. The aim of this study is to evaluate whether an AI-based social software management model could replace human to guide warfarin therapy.

Detailed description

1. The investigators have developed an AI-based miniprogram, and embedded in the Wechat social application. 2. The investigators invited patients receiving warfarin therapy to participant this randomized controlled trial . 3. Participants were randomized to the experimental group and control group in a ratio of 1:1. 4. Participants' warfarin therapy were managed by an AI-based social miniprogram and a Human-based social miniprogram respectively. 5. International normalized ratio(INR) was monitored once a month at least, and the time in therapeutic range was calculated to evaluate the warfarin anticoagulation quality. 6. Participants were followed-up for 24 months, and clinical events, including major bleedings and thrombotic events were recorded during follow-up.

Conditions

• Anticoagulant-induced Bleeding
• Warfarin Sodium Causing Adverse Effects in Therapeutic Use

Interventions

Type	Name	Description
BEHAVIORAL	AI-based social software management model	a AI-based miniprogram, embedded in the Wechat social software, to manage participants' warfarin therapy, such as dose adjustment, INR monitoring alert, etc.
BEHAVIORAL	Human-based social software management model	a Human-based miniprogram, embedded in the Wechat social software, to manage participants' warfarin therapy, such as dose adjustment, INR monitoring alert, etc.

Timeline

• Start date: 2019-05-01
• Primary completion: 2021-04-30
• Completion: 2021-05-01
• First posted: 2019-03-12
• Last updated: 2019-03-12

Locations

2 sites across 1 country: China