Trials / Recruiting
RecruitingNCT03868592
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- Sponsor
- Mayo Clinic · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.
Detailed description
The purpose of this study is to determine whether the adipose inflammatory cell and cytokine content in Class III obesity is related to lipolysis insulin resistance and, if so, whether sustained, substantial weight loss one year following bariatric surgery reduces inflammation in parallel with improved insulin regulation of lipolysis
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Gastric sleeve/bariatric surgery | weight loss |
Timeline
- Start date
- 2019-08-01
- Primary completion
- 2027-05-01
- Completion
- 2027-05-01
- First posted
- 2019-03-11
- Last updated
- 2026-03-03
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03868592. Inclusion in this directory is not an endorsement.