NCT03867214

Effects of Oral Care With Glutamine on Oral Health, Oral Flora and Incidence of Pneumonia After Neurosurgery With Microbiome Analysis

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Yanzhao · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

A randomized, double-blind, single-center and controlled study comparing the efficacy and safety of intravenous administration of tranexamic acid to reduce blood loss in simultaneous bilateral total knee arthroplasty.

Detailed description

A randomized, double-blind, single-center and controlled study comparing the efficacy and safety of intravenous administration of tranexamic acid to reduce blood loss in simultaneous bilateral total knee arthroplasty. Subjects will be monitored for occurrence of any complications, particularly deep venous thrombosis and thromboembolism during the hospital stay and for 1 months postoperatively

Conditions

• Oral Mucositis
• Pneumonia

Interventions

Type	Name	Description
DRUG	Glutamine	1 g of tranexamic acid in 100 mL of normal saline intravenously approximately 15 minutes before incision
DRUG	Normal saline	100 mL of normal saline intravenously approximately 15 minutes before incision

Timeline

• Start date: 2019-01-01
• Primary completion: 2021-03-01
• Completion: 2024-03-01
• First posted: 2019-03-07
• Last updated: 2023-04-27

Locations

1 site across 1 country: China

Regulatory

• FDA-regulated drug study