NCT03867149

Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes

Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes : a Study in Patients With a Thalamic Infarct

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The aim is to expand evidence about the importance of the mediodorsal nucleus of the thalamus as a key node in human higher-order cognitive functions such as learning, decision-making, and adaptive behavior. Thus, the project proposes to assess global cognition along with higher-order cognition integrity via sensitive behavior tasks in patients with well localized lesions (mediodorsal thalamic infarcts) compared with healthy participants.

Detailed description

The recruitment of patients with isolated thalamic lesion after stroke is known to be a challenge that the investigators overcame through the expertise of neurologists within their stroke unit. First, they will describe the cognitive profile consecutive to a lesion of the thalamus, assessed with standardized neuropsychological tests. Second, and more specifically, they will study performances at experimental tasks focusing on higher-order cognition (decision-making, updating, interference managing, multitasking). They will use the automatic localization method already performed : the lesions will be manually segmented from T1 morphologic sequences, and then normalized in a template. Finally a numerical atlas of thalamus will be applied on the lesions, determining the injured substructure and the lesion volume. Besides, this method will be compared with new high resolution thalamus-centered anatomical sequences allowing direct and individual identification of the involved thalamic nucleus.

Conditions

• Thalamic Infarction

Interventions

Type	Name	Description
OTHER	neuroimaging	neuroimaging including high-resolution imaging of the thalamus, DTI and resting state fMRI
OTHER	Neuropsychological assessment	neuropsychological assessment of memory, language, executive functions and mood

Timeline

• Start date: 2019-05-14
• Primary completion: 2023-04-01
• Completion: 2023-04-01
• First posted: 2019-03-07
• Last updated: 2020-01-14

Locations

1 site across 1 country: France