NCT03866512

Forearm Immobilization, Metabolic Health, and Muscle Loss

The Impact of Acipimox and Salbutamol Supplementation on the Development of Insulin Resistance and Anabolic Resistance During Forearm Immobilization in Healthy, Young Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: University of Exeter · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The present study will investigate the impact of altered substrate availability on muscle atrophy, insulin sensitivity and muscle protein synthesis following short-term forearm immobilization

Detailed description

Thirty-six healthy young volunteers will undergo 2 days of forearm immobilization combined with ingestion of one of two drug or placebo. Before and after immobilization, they will receive a stable isotope tracer infusion (5.5 h) combined with repeated blood and muscle sampling under insulin clamp conditions, in order to measure insulin sensitivity and muscle protein synthesis in the fasted and fed state.

Conditions

• Healthy

Interventions

Type	Name	Description
BEHAVIORAL	Forearm immobilization	Two days of forearm immobilization

Timeline

• Start date: 2019-05-10
• Primary completion: 2021-07-01
• Completion: 2021-07-01
• First posted: 2019-03-07
• Last updated: 2024-06-21
• Results posted: 2024-06-21

Locations

1 site across 1 country: United Kingdom