NCT03865355

Blood and Cerebrospinal Fluid Metabolomic Profile in Glioma Patients

Unique Blood and CSF Metabolic Profile Association With Gliomas in Adults

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: Novosibirsk State University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This is an exploratory, non-interventional and translational clinical study. The aim of this study is to analyze blood and cerebrospinal fluid metabolomic profile in glioma patients.

Detailed description

The analysis of metabolic profile in the plasma and CSF could become the new less invasive approach in the establishing diagnosis as well as an important prognostic factor in patients with glioma. The researches will assess the blood and CSF metabolic profile in patients with different types of gliomas as well as in patient without ones. This can help to find new biomarkers for low- and high-grade gliomas correlating with patient outcomes. Blood and CSF samples will be collected from patients with suspected newly diagnosed low-grade (I-II) or high-grade (III-IV) gliomas as well as from patients who have hospitalized for reconstructive surgery after craniofacial trauma. All samples will be collected before any surgical intervention and at various follow-up time points until progression or death. The results of the study are planned to be translated into the hospital setting as support to other diagnostics procedures and to the differential diagnosis between glioma grades.

Conditions

• Glioma
• Glioblastoma Multiforme

Interventions

Type	Name	Description
OTHER	Non- interventional	Translational, observational study

Timeline

• Start date: 2019-03-13
• Primary completion: 2024-04-11
• Completion: 2024-11-11
• First posted: 2019-03-06
• Last updated: 2024-11-14

Locations

1 site across 1 country: Russia