NCT03864276

The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as torsade de pointes,7,8 which has been reported in liver transplantation (LT) surgery. In a previous study, prolonged QTc interval ( 500 msec) was frequently observed throughout the procedure of LT, even among patients with baseline QTc 440 msec. Therefore, it is important to optimize electrolyte balance and hemodynamic status to reduce greater risk of perioperative arrhythmias. The investigators hypothesized that the change of QTc interval might be differ according to method of general anesthesia (inhalation agent vs. intravenous agent).

Conditions

• Liver Cirrhosis(Who Will Undergo Planed Liver Transplantation)

Interventions

Type	Name	Description
DRUG	inhalation (desflurane) group	Anesthesia is induced and maintained with desflurane and sufentanil
DRUG	total intravenous (propofol) anesthesia	Anesthesia is induced and maintained with propofol and sufentanil

Timeline

• Start date: 2019-02-17
• Primary completion: 2020-12-31
• Completion: 2020-12-31
• First posted: 2019-03-06
• Last updated: 2021-10-15

Locations

1 site across 1 country: South Korea