Trials / Completed
CompletedNCT03863041
Study of Phosphorylated Metabolism Profile as Predictive Biomarker of Cognitive Decline in Memory Complaint.
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 49 (actual)
- Sponsor
- Poitiers University Hospital · Academic / Other
- Sex
- All
- Age
- 90 Years
- Healthy volunteers
- Not accepted
Summary
Alzheimer disease is a frequent disease in the late ages that results in global alteration of cognitive functions. In which memory complaint can be isolated in the early stages. Physiopathology of neuronal degenerescence in Alzheimer disease is complex, two main histological lesions are known, amyloid plaques and neurofibrillar tangles. Beyond the histological knowledge, alterations of neuronal metabolism are described such as oxydative phosphorylation and glycolytic pathway. These metabolism alterations are involved in neuronal death. Multi-nucleus magnetic resonance spectroscopy is a non-invasive non-irradiant imagery technique already used in routine. This technic allows the phosphoenergetic pool assessment, that inform about cellular metabolism. The aim of the study is to explore the phosphorylated metabolism patterns as predictive biomarkers of cognitive decline in patients with a memory complaint diagnosed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Additional sequence performed during MRI scan | An additional sequence will be performed during the MRI scan. |
Timeline
- Start date
- 2019-04-08
- Primary completion
- 2023-06-15
- Completion
- 2023-06-15
- First posted
- 2019-03-05
- Last updated
- 2023-10-06
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT03863041. Inclusion in this directory is not an endorsement.