NCT03859947

High-flow Nasal Cannula Flow Rates, Severe Bronchiolitis

Comparison of Heated humidified High-flow Nasal Cannula Flow Rates (1-L/kg/Min vs 2-L/kg/Min) in the Management of Severe Bronchiolitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 168 (actual)
• Sponsor: Ali Yurtseven · Academic / Other
• Sex: All
• Age: 1 Day – 2 Years
• Healthy volunteers: Accepted

Summary

Objective: The investigators aimed to compare the heated humidified high-flow nasal cannula (HHHFNC) flow rate of 1-L/kg/min (1L) with 2-L/kg/min (2L) in patients with severe bronchiolitis presenting to the pediatric emergency department. Study design: The investigators performed a study in which all patients were allocated to receive these two flow rates. The primary outcome was admitted as treatment failure, which was defined as a clinical escalation in respiratory status. Secondary outcomes covered a decrease of respiratory rate (RR), heart rate (HR), the clinical respiratory score (CRS), rise of peripheral capillary oxygen saturation (SpO2) and rates of weaning, intubation and intensive care unit (ICU) admission. Keywords: Bronchiolitis, Emergency department, High-flow nasal cannula, Flow rate

Conditions

• Non-invasive Ventilation
• Pediatric Pulmonary Disease

Interventions

Type	Name	Description
DEVICE	Heated humidified high-flow nasal cannula	Non-invasive ventilation with a nasal cannula

Timeline

• Start date: 2017-05-10
• Primary completion: 2018-10-31
• Completion: 2018-10-31
• First posted: 2019-03-01
• Last updated: 2019-03-01

Locations

1 site across 1 country: Turkey (Türkiye)