NCT03858192

Understanding Acute Sarcopenia

Understanding Acute Sarcopenia: a Time-limited Cohort Study to Characterise Changes in Muscle Mass and Physical Function in Older Adults Following Hospitalisation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 168 (estimated)
• Sponsor: University of Birmingham · Academic / Other
• Sex: All
• Age: 70 Years
• Healthy volunteers: Not accepted

Summary

This study aims to characterise acute changes in muscle mass, strength, physical performance in hospitalised older adults. We will assess the impact of these changes upon physical function at three month follow-up, and assess for the impact of clinical and immune-endocrine factors upon these changes.

Detailed description

Study Design Time-limited cohort study involving serial measurements of Bilateral Anterior Thigh Thickness (BATT) using ultrasound, handgrip strength, physical performance, and physical function measured using the Patient Reported Outcome Measures Information System (PROMIS®). We aim to fully characterise changes in these patients, and will perform a comprehensive evaluation of clinical factors including nutrition and physical activity, and measure immune-endocrine markers of inflammation. Study Participants Elective colorectal surgery, emergency abdominal surgery, and medical patients aged 70 years and older Planned Size of recruitment target 56 elective colorectal patients, 56 emergency abdominal surgery patients, and 56 medical patients with acute infections Follow up duration 3 months Primary research question Does acute change in quadriceps muscle thickness, handgrip strength and/or physical performance within one week of hospitalisation predict change in patient reported physical function at three months?

Conditions

• Sarcopenia

Interventions

Type	Name	Description
PROCEDURE	Colorectal surgery procedure	Elective admission for colorectal surgery
PROCEDURE	Emergency abdominal surgery	Emergency admission necessitating emergency surgery
DRUG	Antibiotics	Treatment for infection and reason for admission

Timeline

• Start date: 2019-05-03
• Primary completion: 2021-07-01
• Completion: 2021-09-01
• First posted: 2019-02-28
• Last updated: 2019-05-21

Locations

1 site across 1 country: United Kingdom