NCT03858153

Exercise and Nutrition Interventions During Chemotherapy K07

The Effects of Exercise and Nutrition Interventions on Chemotherapy-induced Peripheral Neuropathy and Interoceptive Brain Circuitry

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: University of Rochester · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and severe side-effect of taxane chemotherapy, often used to treat breast cancer. Unfortunately there are very limited treatments for CIPN. This is a phase II randomized controlled trial to test the preliminary efficacy of exercise vs. nutrition education on CIPN, to systematically investigate the potential roles of inflammation and interoception, and to obtain data with a more accurate effect size to inform a future study.

Conditions

• Neuropathy;Peripheral

Interventions

Type	Name	Description
BEHAVIORAL	EXCAP Exercise	12 weeks of at-home walking and resistance exercise.
BEHAVIORAL	Nutrition Education	12 weeks of implementing eating tips and tracking food.

Timeline

• Start date: 2019-04-15
• Primary completion: 2025-08-27
• Completion: 2025-08-27
• First posted: 2019-02-28
• Last updated: 2025-12-22

Locations

2 sites across 1 country: United States