NCT03857412

Posterior Capsule Opacification After Lens Capsule Polishing

Evaluation of Intraoperative Capsular Polishing on Lens Epithelial Cells and the Development of Posterior Capsule Opacification

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Prim. Prof. Dr. Oliver Findl, MBA · Academic / Other
• Sex: All
• Age: 21 Years – 105 Years
• Healthy volunteers: Not accepted

Summary

Investigate the effect of polishing of the lens capsule during cataract surgery on the development of posterior capsule opacification

Detailed description

Cataract, the clouding if the eye's lens, is the leading cause of blindness worldwide, with phacoemulsification and implantation of an intraocular lens being the only therapeutic option. Cataract surgery is nowadays considered a safe and efficient procedure. However, one of the most frequent complications after surgery is posterior capsule opacification (PCO), that results in diminished postoperative visual acuity. PCO occurs due to remaining lens epithelial cells in the capsular bag, that start to migrate and proliferate. PCO can be easily treated by performing a neodymium-doped yttrium aluminium garnet (Nd-YAG) laser capsulotomy. However, even if laser capsulotomy is considered a simple procedure, possible complications are rise of intraocular pressure, inflammation, cystoid macular edema, or retinal detachment. Furthermore, several patients are no suitable candidates for laser capsulotomy, for example children and patients with high myopia. Therefore, it would be necessery to identify different approaches to prevent generation of PCO. One approach could be "cleaning" of the lens epithelial cells in the capsular bag by polishing of the lens capsule during surgery. Hence, the aim of this study is to examine whether capsular polishing is beneficial to decrease the growth and proliferation of LECs.

Conditions

• Posterior Capsule Opacification

Interventions

Type	Name	Description
PROCEDURE	Capsular polishing	Capsular polishing taking place during cataract surgery
OTHER	Non capsular polishing	No capsular polishing taking place during cataract surgery

Timeline

• Start date: 2019-02-13
• Primary completion: 2020-05-01
• Completion: 2021-02-01
• First posted: 2019-02-28
• Last updated: 2020-03-16

Locations

1 site across 1 country: Austria