NCT03857087

68Ga-PSMA PET in Diagnosing Metastasis in Patients With Ovarian Cancer

Gallium-68 Prostate Specific Membrane Antigen for Ovarian Cancer: A Pilot Feasibility Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 7 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trial studies how well gallium Ga 68-labeled prostate specific membrane antigen (PSMA)-11 (68Ga-PSMA) positron emission tomography (PET) works in patients with ovarian cancer to detect whether the tumor has spread to other places in the body. 68Ga-PSMA is a radioactive substance that binds to blood vessels around the ovarian cancer and can be imaged using PET. Diagnostic procedures, such as PET, may help find and diagnose find out how far the disease has spread.

Detailed description

PRIMARY OBJECTIVES: I. To determine the feasibility and utility of 68Ga-PSMA PET imaging patients with ovarian cancer. II. Determine detection sensitivity for nodal metastases for PSMA PET stratified by node size. SECONDARY OBJECTIVES: I. To assess the correlation between targeted molecular uptake of 68Ga-PSMA PET and PSMA expression in surgical resection specimens. EXPLORATORY OBJECTIVES: I. To explore heterogeneity of 68Ga-PSMA PET uptake in cases of metastatic ovarian cancer. II. To determine the relationship between 68Ga-PSMA PET uptake, diffusion weighted imaging, and MRI-derived tumor perfusion. OUTLINE: Patients receive gallium Ga 68-labeled PSMA-11 intravenously (IV) over 1-2 minutes. After about 60 minutes, patients undergo PET/magnetic resonance imaging (MRI) for approximately over 50-60 minutes. Patients may undergo an optional repeat gallium Ga 68-labeled PSMA-11 PET between 8 and 12 weeks after completion of the first PET/MRI. After completion of study, patients are followed up at 28 days.

Conditions

• Ovarian Carcinoma

Interventions

Type	Name	Description
DRUG	Gallium Ga 68-labeled PSMA-11	Given IV
PROCEDURE	Magnetic Resonance Imaging (MRI)	Given PET/MRI
PROCEDURE	Positron Emission Tomography (PET)	Undergo PET/MRI

Timeline

• Start date: 2018-04-02
• Primary completion: 2022-06-30
• Completion: 2022-06-30
• First posted: 2019-02-27
• Last updated: 2022-10-12

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study