NCT03856528

Infections of the Central Nervous System

Infections of the Central Nervous System - an Observational Cohort Study

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is to describe the incidence of infectious meningitis and/or encephalitis, and to analyze clinical, diagnostic and treatment characteristics of patients with suspected (and subsequently verified and not verified) infection.

Detailed description

The specific aims of the study include: 1. To assess the incidence, the diagnostic workup, and the treatment characteristics of patients with suspected and confirmed ME. 2. To examine clinical differences between patients with initially suspected and confirmed infectious Meningitis (ME) versus those with suspected but not confirmed infectious ME. 3. To evaluate potentially prognostic factors for pathological CT findings (especially expanding cerebral mass lesions) in patients with suspected infectious ME. 4. To identify a specific group of patients that benefit from cranial CT prior to LP. 5. To examine possible complications (e.g., hematoma, postpuncture headache, cerebral herniation, …) of lumbal punction (LP) and their correlations to pathologic signs on cranial CT. 6. To compare the outcome between patients with suspected infectious ME and cranial CT prior to LP versus patients without prior cranial CT.

Conditions

• Adult Patients With Suspected Meningitis and/or Encephalitis

Interventions

Type	Name	Description
OTHER	collection of patient data	Patient data will be obtained using digital patients records systems. The following data will be assessed: Demographics and baseline patient characteristics (e.g., gender, age, hospital admission and discharge dates), diagnoses, comorbidities (history of meningitis and/or encephalitis, epileptic disorders, remote stroke, remote intracranial bleeding, remote autoimmune disease, neurodegenerative disorders), laboratory features (blood cultures, lumbar puncture), features of neuroimaging (e.g., time admission-to-CT), therapeutic features (incl. time admission-to-treatment), Patients' outcome measures (Glasgow Outcome Score)

Timeline

• Start date: 2019-03-01
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2019-02-27
• Last updated: 2025-02-19

Locations

1 site across 1 country: Switzerland