NCT03855020

Serial Epstein-Barr Virus DNA Surveillance in Nasopharyngeal Carcinoma Patients

Serial Epstein-Barr Virus DNA Surveillance During Treatment in Non-metastatic Nasopharyngeal Carcinoma Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Endemic nasopharyngeal carcinoma (NPC) is invariably associated with Epstein-barr virus (EBV) infection. Plasma EBV DAN detected by polymerase chain reaction (PCR)-based assays can provide important informations of disease screening, disease relapse, and risks classification. In this study, the investigators will explore the impact of serial plasma EBV DNA during chemotherapy and radiotherapy on initial tumor response and long-term survival in patients with non-metastatic nasopharyngeal carcinoma

Conditions

• Nasopharyngeal Carcinoma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Plasma EBV DNA	Parameters analyzed will include (1) the changing pattern of plasma EBV DNA concentrations during chemotherapy and radiotherapy (2) half-life values (t1/2) of plasma EBV DNA clearance rate

Timeline

• Start date: 2019-05-09
• Primary completion: 2022-05-10
• Completion: 2024-05-01
• First posted: 2019-02-26
• Last updated: 2023-06-18

Locations

1 site across 1 country: China