NCT03854539

Salivary Alpha Amylase as a Biomarker of Transdermal Vagus Nerve Stimulation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Arkansas Tech University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The proposed project tests the hypothesis that salivary alpha amylase concentration is a reliable biomarker of the effect of transdermal vagus nerve stimulation (tVNS) in humans.

Detailed description

The study examines the capacity of tVNS to alter the concentrations of salivary alpha amylase. Changes in salivary alpha amylase concentrations reflect alteration of CNS structures anatomically linked to the vagus, thus alertation of alpha amylase would indicate the efficacy of tVNS. This study is intended to study basic mechanisms and is not directed toward the treatment of any disease state. Particapants taking part in the study will spend about one hour in a single session.

Conditions

• No Condition Salivary Alpha Amylase

Interventions

Type	Name	Description
OTHER	Transdermal Vagus Nerve Stimulation	intermittent transdermal stimulation of the aurical vagus

Timeline

• Start date: 2018-03-31
• Primary completion: 2020-06-08
• Completion: 2020-06-08
• First posted: 2019-02-26
• Last updated: 2020-06-18

Locations

1 site across 1 country: United States