Trials / Completed
CompletedNCT03853642
Blood Eosinophil Measurements in Patients With Chronic Obstructive Pulmonary Disease
Blood Eosinophil Measurements Throughout the Day in Patients With Stable Chronic Obstructive Pulmonary Disease
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (actual)
- Sponsor
- Universitair Ziekenhuis Brussel · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This study will assess the within-day variation of blood eosinophils in patients with Chronic Obstructive Pulmonary disease (COPD) in stable state and determine if there is a correlation between the blood eosinophils and certain clinical parameters.
Detailed description
COPD is a heterogeneous disease, resulting in different phenotypes with varying clinical and pathophysiological characteristics. One of these pathophysiological features is chronic airway inflammation which can be eosinophilic of nature. Blood eosinophils could be an accessible biomarker for this eosinophilic inflammation. Eosinophil counts can fluctuate due to their short half-life in blood and due to a diurnal rhythm. More needs to be known about this diurnal rhythm and the different confounding factors and sources of within-subject variability of this biomarker.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Blood sampling | Blood sampling, Spirometry, Fraction exhaled Nitric Oxide |
Timeline
- Start date
- 2019-03-01
- Primary completion
- 2020-03-28
- Completion
- 2020-03-28
- First posted
- 2019-02-25
- Last updated
- 2020-03-30
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT03853642. Inclusion in this directory is not an endorsement.