NCT03850860

Comparison of Two Empirical Antimicrobial Therapies of Prosthetic Joint Infection

Comparison of the Tolerance of Vancomycin in Combination With Piperacillin/Tazobactam or Cefepim as Empirical Antimicrobial Therapy of Prosthetic Joint Infection

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 178 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: —

Summary

The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI). However, the tolerability of such high-dose intravenous regimens is poorly known. T

Detailed description

The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI). However, the tolerability of such high-dose intravenous regimens is poorly known. The empirical antimicrobial therapy of PJI is associated with an important rate of adverse, linked with the use of the vancomycin and the piperacillin-tazobactam combination. Some studies suggest to use vancomycin-cefepime, which remains to be evaluated in PJI.

Conditions

• Bone and Joint Infection

Interventions

Type	Name	Description
OTHER	empirical antibiotherapy	comparison of the outcome in the 2 groups having had 2 different empirical antibiotherapies

Timeline

• Start date: 2018-12-01
• Primary completion: 2019-03-01
• Completion: 2019-06-01
• First posted: 2019-02-22
• Last updated: 2023-09-22

Locations

1 site across 1 country: France