NCT03850002

Lung Clearance Index and Lung Allograft Dysfunction

Lung Clearance Index for the Early Detection and Monitoring of Lung Allograft Dysfunction After Adult Lung Transplantation

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this project is to evaluate the ability of the lung clearance index (LCI) to detect early chronic lung allograft failure (CLAD) in adult lung transplant recipients over a period of 3 years.

Detailed description

This single center study consists of three parts: 1. Characterisation of the Zurich lung transplant cohort regarding CLAD status and pulmonary function impairment (cross-sectional, study part I) 2. Evaluation of test-retest reliability of LCI in 20 clinically stable lung transplant recipients during three consecutive study visits (study part II) 3. Prospective cohort study to test the ability of LCI to detect early CLAD in patients without prior CLAD (study part III)

Conditions

• Lung Transplantation
• Chronic Lung Allograft Dysfunction
• Rejection Lung Transplant

Interventions

Type	Name	Description
OTHER	Early detection of CLAD by Lung Clearance Index (LCI)	Lung transplant candidates without prior CLAD (evaluated in study part I) will be followed over a period of 3 years to evaluate the potential of LCI to detect early CLAD

Timeline

• Start date: 2019-03-01
• Primary completion: 2022-12-31
• Completion: 2023-09-30
• First posted: 2019-02-21
• Last updated: 2019-07-25