NCT03849963

Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 28 (estimated)
• Sponsor: University of Texas Southwestern Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Investigators propose to develop hyperpolarized \[13C\]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral metabolism: oxidative metabolism and synthesis of a neurotransmitter in this observational study.

Detailed description

Investigators will perform a pilot study to test the translational feasibility by evaluating sensitivity and repeatability of hyperpolarized \[1-13C\]pyruvate and \[2-13C\]pyruvate in healthy human subjects (n =10 each). Each subject will be imaged twice using the same hyperpolarized substrate with an interval (\<45min) between the injections to evaluate repeatability. Finally, eight subjects will be imaged with both hyperpolarized \[1-13C\]pyruvate and \[2-13C\]pyruvate for comparison.

Conditions

• Brain Metabolism

Timeline

• Start date: 2030-07-30
• Primary completion: 2030-12-31
• Completion: 2030-12-31
• First posted: 2019-02-21
• Last updated: 2026-03-12

Locations

1 site across 1 country: United States