NCT03849235

A Pathophysiological Study of the Postprandial Human Liver (PLS)

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Copenhagen University Hospital, Hvidovre · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Fatty liver disease is a globally widespread disease The identification of valid biomarkers and targets for potential treatments requires in-depth knowledge about the pathophysiology of the postprandial liver. The study will consist of five work packages (WP) including blood tests and liver biopsies taken after fasting or ingestion of a standardized meal in: healthy controls (WP 1), patients with NAFLD (WP 2), and patients with cirrhosis (WP 3) ; before and after a standardised meal in healthy controls (WP 4), and before and after glucagon in healthy controls (WP5)

Conditions

• Cirrhosis
• Fatty Liver

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Standardised meal or glucagon	Standardised meal (Nutridrink, Nutricia, 300 kcal, 18.4 g carbohydrates, 5.8 g fat, 12 g protein) or 1mg glucagon

Timeline

• Start date: 2019-03-02
• Primary completion: 2022-01-01
• Completion: 2025-01-01
• First posted: 2019-02-21
• Last updated: 2021-01-22

Locations

1 site across 1 country: Denmark