NCT03845790

Pharmacokinetic Study of Vancomycin, Clindamycin And/or Gentamicin Administration During Surgery Using a Microdialysis Procedure

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 25 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective way to prevent surgical site infections. The beta-lactam are the most frequent antibiotics recommended for surgical prophylaxis and patients known to be allergic to beta-lactam are more likely to presented surgical site infection, probably due to use of others antibiotic such as vancomycin or clindamycin. The main objective of the study is to describe the tissu and plasma pharmacokinetics of vancomycin, clindamycin and gentamicin using as surgical antibiotic prophylaxis in patients with beta-lactam hypersensivity and to predict the probability of target attainment for usual bacteria.

Conditions

• Surgical Site Infection

Interventions

Type	Name	Description
OTHER	Blood and microdialysis samples	Blood and microdialisys pharmacocinetic samples on one of the two antibiotics prescribed in routine use

Timeline

• Start date: 2019-05-26
• Primary completion: 2024-09-04
• Completion: 2024-09-04
• First posted: 2019-02-19
• Last updated: 2025-01-16

Locations

1 site across 1 country: France