NCT03844217

Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers

Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers - The Macicop-Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.

Detailed description

Copeptin measurements upon intravenous arginine stimulation discriminate patients with diabetes insipidus versus patients with primary polydipsia with a high diagnostic accuracy. An oral test would be easier to perform, causes less risks and discomfort for the patients and would require less resources in clinical practice. This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.

Conditions

• Polyuria-polydipsia Syndrome

Interventions

Type	Name	Description
DRUG	Macimorelin 0.5mg/kg body weight	oral Macimorelin stimulation test with the dose of 0.5mg/kg body weight Macimorelin
DRUG	Macimorelin 0.75mg/kg body weight	oral Macimorelin stimulation test with the dose of 0.75mg/kg body weight Macimorelin

Timeline

• Start date: 2019-03-07
• Primary completion: 2019-07-16
• Completion: 2019-07-16
• First posted: 2019-02-18
• Last updated: 2019-08-08

Locations

1 site across 1 country: Switzerland