Trials / Unknown
UnknownNCT03842839
Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence Tomography
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- Sponsor
- Guangzhou Institute of Respiratory Disease · Academic / Other
- Sex
- All
- Age
- 40 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
The study aims to explore the effect of tiotropium on airway remodeling by using Endobronchial Optical Coherence Tomography (EB-OCT). We enrolled patients with GOLD I stage COPD. All the patients will be divided into four groups randomly to receive SABA as needed with or without regular use of tiotropium. Changes of airway morphology (accessed by EB-OCT), pulmonary function, QOL, and SABA usage will be obtained.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Tiotropium Inhalation Powder [Spiriva] 0.018mg | Tiotropium bromide (Spiriva) capsule 18μg once daily inhaled. |
| DRUG | Salbutamol sulphate aerosol (Ventolin) 0.01mg | As needed use of salbutamol sulphate aerosol (Ventolin) when exacerbation happens |
Timeline
- Start date
- 2018-10-01
- Primary completion
- 2022-12-01
- Completion
- 2022-12-01
- First posted
- 2019-02-15
- Last updated
- 2022-09-29
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03842839. Inclusion in this directory is not an endorsement.