NCT03841539

Nutrition Interventions for Cognitive Enhancement

Enhanced Mediterranean Diet for Alzheimer's Disease Prevention

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 209 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

By doing this study, researchers hope to learn how the Mediterranean and low-fat eating patterns affect memory, brain volume, brain antioxidant status and cardio-metabolic biomarkers, such as blood pressure and blood glucose, in cognitively normal older adults. Researchers also plan to examine underlying processes relating the patterns to brain health.

Detailed description

Participants will be randomized to either a Mediterranean or low-fat eating pattern. Participation in the study will last about 13 months. Each person will be prescribed one of two eating patterns for 12 months. During the study, participants will be asked to track the food they eat and will be monitored by a registered dietitian. Participants will engage in monthly food demonstrations and cooking classes. Participants will pick up a bag of food items belonging to the prescribed eating pattern, on a weekly basis for 6 months, from a local grocery store chain. Participants have the option to continue in the study for up to 2 years for additional measurements. Potential participants need to be located within the Kansas City metro area.

Conditions

• Alzheimer Disease

Interventions

Type	Name	Description
BEHAVIORAL	Mediterranean Diet	Diet consisting of fruits, vegetables, whole grains, low-fat dairy, olive oil, seafood, nuts and beans. It is low in red and processed meats, solid fats and added sugars.
DIETARY_SUPPLEMENT	Study Supplement	Randomized to take a daily dose of either 2 grams of Omega 3 fatty acids or 2 grams of a Placebo.
BEHAVIORAL	Low-fat Diet	Diet consisting of fruits, vegetables, whole grains, low-fat dairy, and low-fat protein, with fat contributing no more than 25% of calories.

Timeline

• Start date: 2019-03-07
• Primary completion: 2023-03-15
• Completion: 2023-03-22
• First posted: 2019-02-15
• Last updated: 2024-06-07

Locations

1 site across 1 country: United States