NCT03839472

Continuous Bladder Irrigation Following Transurethral Resection of Bladder Tumors

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Case Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this pilot study is to determine if washing out the bladder with large volumes of saline after surgical removal of bladder tumors helps to decrease the number of loose cells floating within the bladder after surgery. Anticipated decrease in tumor recurrence and/or progression rates will be measured.

Detailed description

Bladder tumor recurrence after resection of non-muscle invasive bladder cancer (NMIBC) occurs in 50-70% of patients despite the use of adjuvant anticancer therapy after surgery. This is a single-arm, non-randomized pilot study looking to determine whether post-Transurethral Resection of Bladder Tumor (TURBT) cells counts differ significantly between continuous washout of the bladder (CBI) with normal saline compared to pre-CBI wash out. Anticipated decrease in tumor recurrence and/or progression rates will also be measured, and each participant will act as their own internal control.

Conditions

• Non-muscle Invasive Bladder Cancer (NMIBC)
• Bladder Tumor (TURBT)

Interventions

Type	Name	Description
PROCEDURE	CBI	CBI with 5 liters normal saline in 1 liter increments up to 2 hours after TURBT procedure.

Timeline

• Start date: 2019-09-01
• Primary completion: 2022-09-01
• Completion: 2022-12-01
• First posted: 2019-02-15
• Last updated: 2022-05-11

Locations

1 site across 1 country: United States