NCT03838991

Epigenetic Regulation in Fibrous Dysplasia of Bone: mirDYS Study.

Epigenetic Regulation of Activity and Severity of Fibrous Dysplasia in Bone: mirDYS Study.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Fibrous dysplasia of bone is a rare congenital but non-hereditary disease caused by a post-zygotic activation mutation of the GNAS gene. Patients with fibrous dysplasia may present pain and bone complications (fractures, deformities..) related to their bone lesions. For undetermined reasons, severity and disease evolution may vary considerably from patient to patient. Epigenetic regulation could then be involved, including micro Ribonucleic Acids (miRs). These small non-coding micro Ribonucleic Acids are involved in the regulation of major steps of cellular processes in different pathologies, in particular in bone diseases. However, micro Ribonucleic Acids have never been studied in fibrous dysplasia. The aim of this study is to identify micro Ribonucleic Acids significantly associated with the severity of fibrous dysplasia.

Conditions

• Fibrous Dysplasia of Bone

Interventions

Type	Name	Description
OTHER	Blood sample	A study specific blood sample will be collected.
OTHER	Waste bone tissue	For 3 patients of each group, patients having a scheduled surgery, a piece of waste bone tissue will be collected after surgery.

Timeline

• Start date: 2019-01-10
• Primary completion: 2023-03-24
• Completion: 2023-03-24
• First posted: 2019-02-12
• Last updated: 2025-09-04

Locations

1 site across 1 country: France