NCT03838874

Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty

Double Blind Randomized Clinical Trial Comparing Time To Return of Lower Extremity Motor Function Following Spinal Anesthetic With Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 154 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Days
• Healthy volunteers: Not accepted

Summary

This research is being done to see if there is a difference between two different spinal anesthetics (Mepivacaine vs. Bupivacaine) as it relates to reducing post-operative complications and the time it takes for subjects to regain mobility after surgery.

Conditions

• Knee Osteoarthritis
• Hip Osteoarthritis

Interventions

Type	Name	Description
DRUG	Low-Dose Bupivacaine	10 mg (2 mL of 0.5%) administered as an isobaric spinal anesthetic
DRUG	Mepivacaine	70 mg (3.5 mL of 2%) administered as an isobaric spinal anesthetic

Timeline

• Start date: 2019-02-25
• Primary completion: 2019-10-29
• Completion: 2019-10-29
• First posted: 2019-02-12
• Last updated: 2021-08-12
• Results posted: 2021-08-12

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study