NCT03838328

Dose Effect of Tranexamic Acid on the Incidence of Deep Venous Thrombus in Cardiac Surgery

Dose Effect of Tranexamic Acid on the Incidence of Deep Venous Thrombus in Cardiac Surgery With Cardiopulmonary Bypass

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 360 (estimated)
• Sponsor: SHI Jia · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

In recent years, the lysine analogs tranexamic acid (TXA) has gained wide use in cardiac surgery as a blood-sparing agent. However, the safety of the drug and its impact on overall outcomes of cardiac surgery remains debated. The current study evaluates the dose effect of TXA on the incidence of deep venous thrombus (DVT) in cardiac surgery with cardiopulmonary bypass. Also, the dose effect of TXA on bleeding and allogeneic transfusion is evaluated.

Conditions

• Thromboses, Deep Vein
• Tranexamic Acid Adverse Reaction

Interventions

Type	Name	Description
DRUG	Tranexamic Acid	Tranexamic acid will be delivered by loading dose plus maintenance infusion until the end of the operation.

Timeline

• Start date: 2019-03-01
• Primary completion: 2020-02-28
• Completion: 2020-03-31
• First posted: 2019-02-12
• Last updated: 2019-02-12

Locations

1 site across 1 country: China