NCT03835624

Interleukin 33 in Juvenile Idiopathic Arthritis Patients

Interleukin 33 in Juvenile Idiopathic Arthritis Patients :Relation to Disease State and Muscloskeletal Ultrasound Findings

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to measure serum and synovial fluid levels of IL 33 and its relative mRNA expression in peripheral blood mononuclear cells in juvenile idiopathic arthritis (JIA) patients and to correlate it with the clinical and laboratory characteristics, disease activity and musculoskeletal ultrasound findings.

Detailed description

SUBJECTS AND METHODS Subjects:This study will be a case-control study including sixty children with juvenile idiopathic arthritis attending pediatric rheumatology clinic of Benha University Hospital and Benha children hospital and thirty apparently healthy children as controls. They will be classified into: * Group (I) study group:60 cases of children with juvenile idiopathic arthritis. * Group (II) Control group:60 of apparently healthy children matched for age and sex A)Full history taking B) Full clinical examination C) Clinical assessment of disease activity D) Laboratory Investigations: All subjects will be investigated by 1. complete blood count. 2. Erythrocyte sedmentation rate. 3. C-reactive protein . 4. Liver enzymes: ALT and AST. 5. Rheumatoid factor. 6. Antinuclear antibody (ANA). 7. serum ferritin 8. serum and synovial fluid Interleukin 33 by ELISA and its relative expression in peripheral blood mononuclear cells by PCR E) Musculoskeletal Ultrasound examination

Conditions

• Juvenile Idiopathic Arthritis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	interleukin 33	serum and synovial fluid samples will be obtained from patients and serum samples from controls to measure interleukin 33 and its relative mRNA expression in peripheral blood mononuclear cells by PCR

Timeline

• Start date: 2019-02-12
• Primary completion: 2019-11-20
• Completion: 2019-11-20
• First posted: 2019-02-08
• Last updated: 2019-12-11

Locations

1 site across 1 country: Egypt